挥发性有机化合物呼吸测试在非癌症胃肠道疾病中的前景和挑战
Weiyang Zheng1, Ke Pang2, Yiyang Min2
1Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Biomedicines
|August 29, 2024
概括
呼吸中的挥发性有机化合物 (VOC) 在诊断诸如GERD,IBD和肝脏疾病等非癌症疾病方面表现有前途. 进一步的研究可以将呼吸分析作为一种有价值的非侵入性诊断工具.
科学领域:
- 生物标志物和诊断方法
- 非侵入性疾病检测检测非侵入性疾病检测
- 挥发性有机化合物 (VOC) 分析分析
背景情况:
- 呼吸分析是一种未充分利用的生物矩阵,具有历史的诊断应用.
- 挥发性有机化合物 (VOC) 尚未被确立为临床验证的疾病生物标志物.
- 专注于晚期或恶性疾病生物标志物具有有限的临床相关性.
研究的目的:
- 审查VOC呼吸测试在诊断非癌症疾病方面的潜力.
- 探索在癌前疾病,炎症性肠道疾病和慢性肝病中的应用.
- 评估VOC呼吸测试作为对现有诊断标准的补充工具.
主要方法:
- 在EMBASE,MEDLINE和Cochrane数据库中进行文献搜索.
- 24项研究的概述,重点是分析平台,疾病类型/阶段和研究参数.
- 探索VOC用于非侵入性诊断和疾病监测的利用.
主要成果:
- 确定了需要审查的24项相关研究.
- 讨论了研究特征,包括分析平台和诊断性能.
- 突出了VOCs的潜力,以补充当前的诊断方法.
结论:
- 挥发性有机化合物呼吸试验为诊断非癌症疾病提供了潜力.
- 完善研究设计和采样可以提高对VOC代谢途径的理解.
- 呼吸分析可以成为差异诊断和疾病监测的有效非侵入性方法.
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