抗氧化剂作为防治由甲 (FA) 暴露引起的反应性氧压力的保护:系统性审查
Loredana Beatrice Ungureanu1, Cristina Mihaela Ghiciuc2, Cornelia Amalinei3
1Morphopathology, Department of Morpho-Functional Sciences I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
Biomedicines
|August 29, 2024
概括
抗氧化剂可以防止甲引起的氧化应激和损伤. 需要进一步的人体研究来确认这些保护作用并优化抗氧化剂的使用.
科学领域:
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
- 致癌的发生是致癌的产生.
背景情况:
- 甲 (FA) 是一种已知的致癌物质,可诱导氧化应激.
- 暴露于FA会影响多个器官,包括呼吸道,角膜,肝脏,脏,大脑和心血管系统.
- 鼻区域的状细胞癌是一个特别令人担忧的问题.
研究的目的:
- 研究抗氧化剂在缓解甲诱导的氧化损伤方面的潜力.
- 审查关于抗氧化剂对FA毒性的保护作用的现有文献.
主要方法:
- 在主要科学数据库 (PubMed,Science Direct,Springer,Wiley) 的系统文献搜索.
- 包括对抗氧化剂减轻FA引起的氧化损伤的研究;不包括评论和不完整的文章.
- 使用SYRCLE的偏差风险工具进行动物研究;通过表格进行数据综合. 从8790篇文章中选择了35篇出版物进行详细分析,包括生物化学,组织病理学和免疫组织化学数据.
主要成果:
- 抗氧化剂,包括植物提取物,维生素和颜料,在预防或治疗甲引起的病变方面表现出有效性.
- 研究主要利用动物模型 (老鼠,小鼠) 进行病例对照设计,其中有一项对工业工人的队列研究.
结论:
- 抗氧化剂在抵消甲有害作用方面显示出有前途.
- 在进行人体研究,特别是活检方面,仍然存在挑战.
- 进一步的研究对于验证长期效果和确定最佳抗氧化剂剂量至关重要.
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