慢性精神兴奋剂对骨健康的影响:一篇综述
Jessica Nowak1, Jacob Aronin1, Faraaz Beg1
1Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Biomedicines
|August 29, 2024
概括
甲基化物 (MP) 和安非他命 (AMP) 是常见的ADHD治疗方法. 慢性使用这些精神兴奋剂可以通过增加骨质细胞活性来对骨健康产生负面影响,这可能会影响骨折愈合.
科学领域:
- 药理学 药理学是指药理学的学科.
- 骨生物学 骨生物学 骨生物学
- 神经科学是一个神经科学.
背景情况:
- 甲基化物 (MP) 和安非他命 (AMP) 是广泛用于治疗ADHD和麻醉症的精神兴奋剂.
- 大约有600万儿童被诊断患有多动症,其中很大一部分接受精神兴奋剂处方.
- 骨质平衡,生物力学特性和功能完整性是整体健康的关键方面.
研究的目的:
- 审查和综合当前关于精神兴奋剂使用对骨健康影响的文献.
- 调查MP和AMP对骨质平衡,生物力学特性和功能完整性的影响.
- 了解影响骨重塑和强度的下游机制.
主要方法:
- 使用Medline/PubMed.Med进行了全面的文献搜索.
- 搜索术语包括"甲基化物"",安非他胺"",骨健康"",骨改造"",骨质细胞"",骨质细胞"和"多巴胺".
- 搜索涵盖了1985年1月至2023年4月的出版物,其中44项研究符合纳入标准.
主要成果:
- 数据表明,MP和AMP的使用导致骨特性和生物机械完整性下降.
- 这些效应是由下游对骨质母细胞和骨质母细胞相关基因表达的影响介导的.
- 具体来说,骨质细胞活性增加被确定为一个关键因素.
结论:
- 慢性精神兴奋剂的使用会对骨的完整性和强度产生不利影响.
- 骨质细胞活性增加是导致这些负面影响的主要机制.
- 对精神兴奋剂治疗的持续时间和类型的临床考虑是有必要的,特别是在骨折的情况下.
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