在瘤学环境中的生物重建中的移植感染:对文献的系统审查
Andrea Sambri1, Renato Zunarelli1, Lorenzo Morante1
1Orthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Journal of clinical medicine
|August 29, 2024
概括
骨瘤手术后,生物移植感染很常见,特别是在骨盆和骨. 两阶段的修复和移植切除提供了克服感染和确保重建的最佳机会.
科学领域:
- 整形瘤学 整形瘤学
- 传染性疾病 传染性疾病
- 生物材料科学 生物材料科学
背景情况:
- 生物移植感染 (BGI) 是骨瘤重建性手术后的一个重要并发症.
- 关于BGI流行病学和治疗结果的现有文献有限,通常基于稀疏的病例报告.
- 对BGI的全面理解对于改善瘤切除后的患者管理至关重要.
研究的目的:
- 系统地审查和收集有关瘤切除后生物移植感染的综合数据.
- 分析不同解剖部位和移植类型的BGI的发生率,治疗策略和结果.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了系统的文献搜索.
- 纳入标准用于确定在瘤切除后报告BGI的相关研究.
- 交叉引用文献资料以确保全面的文章检索.
主要成果:
- 分析了139项涉及9824个移植的研究.
- 在骨盆 (20.4%) 和骨 (11.0%) 观察到的BGI发病率最高.
- 脱皮和植入物保留 (DAIR) 是最常见的初始治疗方法 (42.8%),其次是两阶段的修订和移植移除 (34.8%).
结论:
- 骨瘤切除后的生物重建显示出感染的高发病率.
- 虽然DAIR是一种潜在的治疗方法,但采用切片切除和内置假肢重建的两阶段方法在解决感染方面取得了更高的成功.
- 未来的多中心研究对于完善骨肉瘤生物重建后感染的管理方案至关重要.
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