在患有COVID后抑郁症的患者中脱素化
Marina Khodanovich1, Mikhail Svetlik1, Daria Kamaeva1,2
1Laboratory of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University, 36 Lenina Ave., Tomsk 634050, Russia.
Journal of clinical medicine
|August 29, 2024
概括
后COVID抑郁症涉及白色和灰色物质大脑结构的广泛脱髓化. 在下面的前后囊中脱化是这种情况的关键生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 抑郁症是COVID-19的一个重要后果.
- 大型抑郁症涉及由于大脑髓化变化而破坏白质 (WM) 连接.
- 后COVID抑郁症 (PCD) 需要对大脑髓化进行定量评估.
研究的目的:
- 在临床诊断的COVID后抑郁症 (PCD) 中量化评估大脑髓化.
- 为此评估,利用宏分子质子分数 (MPF) 映射,一种新的MRI技术.
主要方法:
- 研究了63名康复的COVID-19患者和19名对照组.
- 参与者被分为COVID后抑郁症 (PCD,n=25) 和没有PCD (n=38) 组.
- 宏分子质子分数 (MPF) 映射用于评估大脑髓化.
主要成果:
- PCD患者在WM中表现出广泛的脱髓化 (皮下皮层,IFOF等). 和转基因 (海马体,杏仁体等). ) 的情况.
- 没有PCD组也表现出脱髓化,但程度较小.
- 下面的前后囊 (IFOF) 脱髓化预测了PCD的存在和严重程度.
结论:
- 这项研究提供了第一个证据,证明PCD中WM和GM结构中广泛的脱髓化.
- 较低的前后带 (IFOF) 脱髓化被确定为PCD的一个关键生物标志物.
关键词:
在 COVID-19 疫情中,在MPF的MPF.这就是为什么MRI是MRI.脱化是脱化的一种.抑郁 抑郁症 抑郁症 抑郁症 是一种长时间的COVID.大分子质子分数的大分子质子分数.磁共振成像技术的使用大型抑郁症主要是抑郁症.在COVD后的时间.白质是白色物质的组成部分.更多相关视频
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