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患有状细胞疾病的个体的急性胰腺炎:系统性审查
Chinenye R Dike1, Adefunke DadeMatthews2, Oluwagbemiga DadeMatthews3
1Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
状细胞病 (SCD) 患者患急性胰腺炎 (AP) 的风险更高. 关于SCD中AP流行率和严重程度的数据有限,需要进一步研究以获得更好的诊断和结果.
科学领域:
- 血液学 血液学 血液学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 状细胞病 (SCD) 影响了美国10万个人,增加了胆结石和缺血的风险.
- 这些并发症可能会增加SCD患者急性胰腺炎 (AP) 的风险.
- 腹痛是AP和状细胞血管封闭性危机的共同症状,使诊断复杂化.
研究的目的:
- 系统地审查和估计患有SCD的个体中AP的流行率.
- 为了确定与一般人群相比,SCD患者的AP严重程度.
主要方法:
- 对多个电子数据库进行系统审查.
- 包括对儿科和成人群体的研究,将SCD患者与没有AP的SCD患者进行比较.
- 标题/摘要的独立选和重复的数据抽象.
主要成果:
- 从296项选中,确定了33项研究,包括病例报告,病例系列和回顾性队列.
- 在SCD病例中AP并发症包括呼吸系统问题,脏并发症,胰腺伪囊和一个死亡.
- 在两项研究中,SCD中估计的AP患病率在2%至7%之间;作为SCD儿童的AP病因,胆道疾病为12%至34%.
结论:
- 目前关于SCD患者AP患病率的数据有限.
- 需要进行前性研究,以便在出现腹痛的SCD患者中主动评估AP.
- 改进的诊断策略对于及时的AP诊断和SCD中更好的结果至关重要.
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Acute Pancreatitis II: Clinical Manifestations and Management
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Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: