心脂肪组织和牛皮:一个系统的审查和元分析
Xiaomei Chen1, Hongmei Xiang1, Jing Lu2,3
1Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Journal of clinical medicine
|August 29, 2024
概括
心脏脂肪组织 (EAT) 是心血管疾病的标志物,在牛皮患者中显著增加. 这一系统性审查证实,EAT厚度和面积与牛皮有关,但不是EAT体积.
科学领域:
- 心脏病学 心脏病学
- 皮肤病学 皮肤病学
- 医学生物标志物 医学生物标志物
背景情况:
- 心脂肪组织 (EAT) 是心血管疾病的新兴生物标志物.
- 之前的研究表明,EAT和牛皮之间存在联系.
- 本研究提供了对这种关系的最新系统审查.
研究的目的:
- 系统地审查和综合目前关于心表脂肪组织 (EAT) 和牛皮之间的关联的证据.
- 以此前的报告为基础,对EAT与牛皮的关系进行最新分析.
主要方法:
- 在Medline,Embase和Cochrane控制试验中央登记处进行了系统的文献搜索.
- 使用纽卡斯尔-太华尺度评估所包含研究的方法质量.
- 计算的聚合平均差异 (MD) 或标准化平均差异 (SMD) 使用95%的置信区间 (CI).
主要成果:
- 包括10项研究,共有1287名参与者,5项高质量,5项中等质量.
- 与对照组相比,牛皮患者的EAT显著增加 (SMD 1.53).
- 亚组分析显示,在牛皮患者中,EAT厚度 (SMD 2.45) 和CT确定EAT面积 (SMD 0.45) 显著增加. EAT 量显示不显著增加 (SMD 0.32).
结论:
- 心脂肪组织 (EAT),特别是它的厚度和面积,与牛皮有显著的关联.
- 通过心声回声学测量的EAT厚度和CT确定的EAT面积是与牛皮有关的关键指标.
- 在本次审查中,CT确定的EAT体积没有显示出与牛皮的统计学上显著的关联.
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