基于抗体的细胞免疫疗法的高风险神经母细胞瘤挑战和机会
Natasha V Persaud1, Jeong A Park2, Nai Kong V Cheung1
1Department of Pediatrics Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Journal of clinical medicine
|August 29, 2024
概括
免疫疗法为高风险神经母细胞瘤 (NB) 提供了一个有希望的途径. 本综述探讨了免疫策略,包括针对GD2的新型T细胞疗法,以改善NB患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 神经母细胞瘤 (NB) 是交感神经系统的异质癌症,尽管进行了密集治疗,但治疗率约为50%.
- 复发性或耐药性高风险神经母细胞瘤 (HRNB) 存在重大治疗挑战.
- 风险分层和适应阶段的疗法改善了结果,但治疗挑战仍然存在.
研究的目的:
- 审查目前神经母细胞瘤 (NB) 的免疫方法.
- 在NB免疫治疗的背景下讨论瘤微环境 (TME).
- 为HRNB提出一种新的基于T细胞的治疗策略.
主要方法:
- 对神经母细胞瘤免疫治疗现有文献的综述.
- 免疫策略的分析,包括单克隆抗体,疫苗和采用细胞疗法.
- 瘤微环境 (TME) 的探索及其在NB病原和治疗中的作用.
主要成果:
- 免疫疗法,包括单克隆抗体等向药物,是复发/耐药HRNB的一个有吸引力的选择.
- 采用细胞疗法及其组合显示出潜力,但面临毒性问题.
- 利用瘤表面抗原,如类GD2是一种关键策略.
结论:
- 基于T细胞的新型免疫疗法有望提高高风险神经母细胞瘤的治愈率.
- 将采用细胞疗法的进展与基于抗体的方法相结合,可以克服当前的局限性.
- 对TME调节的进一步研究对于优化NB免疫疗法至关重要.
相关概念视频
01:27Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K