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在COVID-19患者中循环阿迪波金水平的变化

Tomasz Wikar^1,2, Mateusz Rubinkiewicz¹, Dominika Stygar³

¹2nd Department of General Surgery, Jagiellonian University Medical College, 31-066 Kraków, Poland.

Journal of clinical medicine

|August 29, 2024

概括

COVID-19 感染显著降低了视沙丁水平,在住院期间正常化. 莱普水平在COVID-19患者中没有显著差异,但与BMI相关. 需要进一步的研究.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

由SARS-CoV-2引起的COVID-19大流行给全球健康带来了重大挑战.
了解COVID-19患者的炎症反应对于有效管理至关重要.
阿迪波基因,如维斯法丁和丁,在炎症和代谢过程中起作用.

研究的目的:

为了研究与健康对照组相比,COVID-19患者血清维斯法廷和丁度的变化.
探索这些阿迪波金与疾病进展或严重程度之间的相关性.
评估维斯法丁和瘦素作为COVID-19生物标志物的潜力.

主要方法:

血清样本从40名COVID-19患者和24名健康对照患者在入院时和第7天收集.
使用酶免疫检测或ELISA套件测量了维斯法丁和瘦素度.
统计分析包括沙皮罗-威尔克测试,曼-惠特尼U测试,克鲁斯卡尔-瓦利斯ANOVA和斯皮尔曼等级相关性.

主要成果:

与对照组相比,COVID-19患者在入院时的血清维斯法廷水平显著降低 (p < 0.001).
在COVID-19患者中的Visfatin水平在住院7天后正常化至控制水平.
在COVID-19患者和对照人群之间没有观察到瘦素水平的显著差异 (p = 0.270,p = 0.129);然而,瘦素与BMI正相关 (r = 0.66,p = 0.00).

结论:

COVID-19 感染的发作与视法丁水平显著降低有关.
莱普在COVID-19病变发生中的作用需要进一步调查,其水平受到BMI的影响.
需要进行额外的研究,以澄清维斯法丁和丁在SARS-CoV-2感染中的作用及其预后价值.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.这是一种阿迪波基因 (adipokine).冠状病毒冠状病毒的新冠病毒.勒普丁是一种素.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖在VISFATIN中

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