身体活动和尿路分泌循环节律:基于人口的横截面试点研究
Martina Zandonà1, Jakub Novotny2, Maria Luisa Garo3
1Clinical Research Unit, Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Journal of clinical medicine
|August 29, 2024
概括
身体活动不会影响分泌的昼夜节律,尽管它已知对血压和心血管健康有好处. 这表明,其他机制也在发挥身体活动的作用.
科学领域:
- 心血管生理学心血管生理学
- 脏生理学 脏生理学
- 时间生物学 时间生物学
背景情况:
- 血压 (BP) 呈现出昼夜节律,夜间下降,这种模式与心血管疾病 (CVD) 风险有关.
- 尿路分泌的日间节律 (NaCle) 与血压模式相关,在白天达到峰值.
- 身体活动 (PA) 可以改善血压控制和降低血压,但其对NaCle节律的影响尚不清楚.
研究的目的:
- 研究身体活动 (PA) 与尿路分泌 (NaCle) 的昼夜节律之间的相关性.
- 为了确定这种关系是否独立于年龄,性别,血压,浸泡状态和盐摄入量.
主要方法:
- 对953名来自蒂西诺流行病学硬性研究的参与者的试点横截面分析.
- 通过问卷,血液样本,24小时尿液收集和门诊血压监测收集的数据.
- 参与者按PA水平 (静止,部分活跃,活跃) 分类;用于评估PA,NaCl摄入量和浸泡对日夜NaCle比率的影响的多变量线性回归.
主要成果:
- 白天/夜间NaCle比率与浸泡模式正相关.
- 身体活动 (PA) 与NaCle比率没有显著的相关性.
- 较高的盐摄入量与高血压相关,特别是在男性和年轻人中.
结论:
- 白天/夜间NaCle比率与BP浸泡模式有关,但PA与脏处理的昼夜节律无关.
- 似乎PA对心血管的益处是通过独立于NaCle昼夜节律的机制来调解的.
- 需要进一步的研究来阐明PA通过哪些特定途径影响BP和心血管健康.
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