激素替代疗法和基于正念的压力减轻对降低风险的卵管切除术后高潮症状的影响
Amira Mohammed Ali1, Saeed A Al-Dossary2, Carlos Laranjeira3,4,5
1Department of Psychiatric Nursing and Mental Health, Faculty of Nursing, Alexandria University, Smouha, Alexandria 21527, Egypt.
Healthcare (Basel, Switzerland)
|August 29, 2024
概括
激素替代疗法 (HRT) 可以缓解 BRCA1/2 突变的妇女的更年期症状,接受降低风险的卵管切除术 (RRSO). 基于正念的压力减轻 (MBSR) 可能会使症状恶化,这表明细胞氧化还原平衡受到干扰.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 妇女健康 妇女健康
- 绝经研究 绝经研究
背景情况:
- 由于BRCA1/2突变增加了癌症风险,因此需要进行降低风险的salpingo-oophorectomy (RRSO).
- RRSO会导致雌激素的急剧下降,导致严重的绝经症状和潜在的氧化还原失败.
- 在RRSO后的BRCA1/2携带者中,HRT和MBSR对更年期症状的影响尚不清楚.
研究的目的:
- 检查HRT和MBSR对接受RRSO的女性更年期症状的影响.
- 确定可能从这些干预中受益或受到这些干预的不利影响的患者子组.
主要方法:
- 使用路径分析来评估HRT和MBSR的直接和间接影响.
- 该研究包括199名接受RRSO的患者,平均年龄为50.5岁.
- 进行了多组分析,以探索子组差异.
主要成果:
- HRT直接减少了泌尿器官症状,并间接影响了体质植物和心理症状.
- 在BRCA2携带者,身体活跃的妇女,高BMI的妇女和没有乳腺癌史的妇女中,HRT的益处更为明显.
- MBSR与体质植物性和心理症状的间接增加有关,并在一些子组中表现出不利的直接影响.
- 在有癌症史的女性中,HRT恶化了泌尿器官症状.
结论:
- 在RRSO后的年轻女性可能会从个性化的HRT中受益,但需要持续的心理支持.
- 在这个人群中,MBSR可能会对更年期症状产生负面影响,可能是通过干扰氧化还原灵敏度.
- 需要进一步的研究来阐明MBSR对BRCA1/2载体影响的机制.
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