母亲暴露于低剂量的BDE-47诱导了后代的体重增加和胰岛素敏感性受损
Sandra Strunz1,2, Rebecca Strachan1, Mario Bauer1
1Helmholtz Centre for Environmental Research-UFZ, Department of Environmental Immunology, 04318 Leipzig, Germany.
International journal of molecular sciences
|August 29, 2024
概括
母亲接触BDE-47等阻燃剂可能会导致后代体重增加和代谢问题. 这项研究揭示了涉及脂肪生成和瘦素信号干扰的潜在机制.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 聚二乙烯 (PBDE) 是消费品中发现的阻燃剂.
- 孕产妇暴露于PBDE与更高的儿童BMI和代谢障碍有关.
- 不完全理解PBDE对后代代谢健康的因果关系和机制.
研究的目的:
- 调查母亲暴露于BDE-47对后代体重增加和能量恒温的影响.
- 探索代谢途径损害后代的潜在机制.
主要方法:
- 用小鼠模型来检查在妊娠期间低剂量BDE-47暴露的影响.
- 在体外和体内实验评估了脂肪生成,葡萄糖/胰岛素耐受性和基因表达.
- 分析了大脑中的勒素信号通路.
主要成果:
- 母亲暴露于BDE-47导致雌性后代体重增加.
- 雄性和雌性后代均表现出葡萄糖和胰岛素耐受性受损.
- 有证据表明,BDE-47诱导脂肪生成,可能是通过DNA高甲基化.
- 通过改变叶黄素信号传递,观察到神经元对能量平衡的调节失调.
结论:
- 早期接触BDE-47可能会破坏后代的能量代谢并促进体重增加.
- 机制包括增加脂肪生成和受损的瘦素信号传递.
- 这些发现突出了PBDE作为潜在的内分泌干扰物,影响代谢健康.
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