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TAS2R38基因型不会影响SARS-CoV-2感染的初级状腺失灵症

Gioia Piatti¹, Giorgia Girotto², Maria Pina Concas³

¹Department of Pathophysiology and Transplantation, University of Milan and Unit of Bronchopneumology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.

International journal of molecular sciences

|August 29, 2024

概括

患有初级动力障碍症 (PCD) 的人似乎不会面临严重COVID-19结果的更高风险. 此外,TAS2R38苦味受体基因型也没有影响该人群的SARS-CoV-2感染易感性.

科学领域:

遗传学遗传学是一个
免疫学免疫学免疫学
肺部病理学肺部病理学

背景情况:

初级状腺失动症 (PCD) 是一种罕见的遗传性疾病,影响呼吸道状腺,导致经常性感染.
慢性呼吸道疾病是SARS-CoV-2感染的潜在风险因素.

研究的目的:

调查PCD患者是否对SARS-CoV-2感染的易感性增加.
确定TAS2R38苦味受体基因多态是否与PCD患者的SARS-CoV-2感染流行率和症状严重程度相关.

主要方法:

一组由40名成人PCD患者组成的队列填写了有关SARS-CoV-2感染,症状和疫苗接种状态的问卷.
COVID-19 阳性患者还填写了 SNOT-22 和 ARTIQ 问卷.
进行了TAS2R38多态的基因定型.

主要成果:

30%的PCD患者报告COVID-19诊断,大多数有轻微症状.
观察到身体质量指数 (BMI) 的统计学上显著差异,在COVID-19阳性组中更高 (p=0.03).
没有发现TAS2R38的PAV等位基因对SARS-CoV-2感染有保护作用.

结论:

PCD患者可能不会面临严重COVID-19的风险增加.
TAS2R38苦味受体基因型似乎不会影响PCD患者的SARS-CoV-2感染.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.这就是TAS2R3838的情况.苦味受体是苦味的受体.主要的状动力障碍症.

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