精选的唾液衍生的细胞因子和生长因子在儿科牙面部炎症中升高
相关实验视频
Updated: Jun 14, 2025

09:46
Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
3.6K
Bogusława Orzechowska-Wylęgała1, Adam Wylęgała2, Jolanta Zalejska Fiolka3
1Department of Pediatric Otolaryngology, Head and Neck Surgery, Medical University of Silesia (SUM), 40-055 Katowice, Poland.
International journal of molecular sciences
|August 29, 2024
概括
像IL-4和IL-15这样的唾液生物标志物可以帮助识别儿童的急性牙面部感染. 这些发现有助于监测和治疗由牙损伤引起的口腔炎症.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 儿科牙科 儿科牙科
背景情况:
- 未经治疗的牙损伤会导致严重的牙面部炎症,可能会扩散到更深层的组织.
- 确定儿童急性牙感染的可靠生物标志物对于及时干预至关重要.
研究的目的:
- 对患有急性牙面部感染 (DI) 的儿童进行唾液细胞因子分析,与患有无并发性牙损伤 (CE) 的儿童进行比较.
- 确定潜在的唾液生物标志物,用于诊断和监测儿科牙感染.
主要方法:
- 使用Bio-Plex Pro人类细胞因子27-Plex套件分析了唾液细胞因子配置文件.
- 该研究包括28名DI儿童和52名控制组儿童 (CE).
主要成果:
- 与对照组相比,在患有DI的儿童中观察到IL-4,IL-15,FGF-2,G-CSF和PDGF-BB的水平升高.
- 两组之间IL-2,IL-7,IL-9,IL-13,GM-CSF和IFN-γ水平没有发现显著差异.
结论:
- IL-4,IL-15,FGF-2,G-CSF和PDGF-BB显示出作为儿童口腔炎的选择性生物标志物的潜力.
- 这些生物标志物可能有助于识别和管理导致牙和面部炎症的细菌感染.
相关概念视频
Salivary Glands and Saliva
516
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
516
Role of Hematopoietic Growth Factors
1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K

