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准皮达尔吉宁减弱酶3以有效抑制疹简单病毒2型感染

Selina Pasquero1, Francesca Gugliesi1, Matteo Biolatti1

  • 1Department of Public Health and Pediatric Sciences, Medical School, University of Turin, 10124 Turin, Italy.

International journal of molecular sciences
|August 29, 2024
PubMed
概括

简单疹病毒2型 (HSV-2) 感染上调蛋白质氨酸衰减酶 (PADs),特别是PAD3. 抑制PAD3显著减少HSV-2复制,这表明PAD3是HSV-2的治疗标.

关键词:
素化是指素化.简单疹病毒2型 (HSV-2)针对宿主的抗病毒药物 (HTAs)蛋白质阿尔金因减弱酶3型 (PAD3,PADI3) 的发生.

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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