2型糖尿病和与代谢功能障碍相关的脂肪性肝病之间的病理生理关系:新的治疗方法
Shifat-E Ferdous1,2, Jessica M Ferrell1,2
1Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
International journal of molecular sciences
|August 29, 2024
概括
2型糖尿病 (T2DM) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 经常共存并相互恶化. 了解它们的相互作用是寻找这些日益严重的全球健康问题的新疗法的关键.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 影响全球数百万人,通常导致高血糖和胰岛素抵抗.
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是代谢综合征的肝脏表现,在全球范围内越来越普遍.
- T2DM和MASLD经常同时发生,大多数T2DM患者患有MASLD,反之亦然,这表明有协同作用的关系.
研究的目的:
- 为了阐明T2DM和MASLD之间的致病相互作用.
- 探索这些条件的协同恶化背后的机制.
- 确定新的治疗点,并审查正在进行的治疗T2DM和MASLD的临床试验.
主要方法:
- 文献综述侧重于T2DM和MASLD之间的相互作用.
- 分析病理生理机制,包括脂毒性和炎症.
- 检查当前和新兴的治疗策略.
主要成果:
- T2DM和MASLD表现出一种协同作用的关系,可能是由肝脏脂毒性和炎症驱动的.
- 驱动这种相互作用的精确机制以及改善一个条件如何影响另一个条件需要进一步澄清.
- 一些新的治疗点和临床试验正在调查中.
结论:
- 由于T2DM和MASLD的复杂相互作用,T2DM和MASLD的同时发生构成了重大的临床挑战.
- 进一步研究共享的病理生理路径对于开发有效的综合治疗策略至关重要.
- 突出新的治疗目标和正在进行的试验为改善患者治疗结果提供了希望.
相关概念视频
01:36Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
01:20Pathophysiology of Diabetes
908
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
908
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:15Diabetes: Management and Pharmacotherapy
245
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
245
01:22Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
01:24Overview of Lipid Metabolism
1.2K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.2K