Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genomic profiling as an option for ovarian cancer diagnostics.

Expert review of molecular diagnostics·2026
Same author

Enhanced Liver Fibrosis Test, FIB-4 and FibroScan: Real-World Prognostic Accuracy for MASLD in a Biopsy-Controlled Cohort.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

LANTERN 2: Association Between Gene Molecular Profile and STAS in Lung Adenocarcinoma: A Comparative Analysis in a Prospective Real-World Population.

Genes·2026
Same author

Longitudinal Trends of Salivary Oxidized Thymosin β4 and β10 in Preterm Infants with Bronchopulmonary Dysplasia.

Children (Basel, Switzerland)·2026
Same author

Proteomic profile of bone in patients with acromegaly: new insights from a pilot exploratory study.

Journal of endocrinological investigation·2026
Same author

Human Chorionic Gonadotropin (hCG)-Induced Remodeling of the Granulosa Cell Exosomal Proteome: Implications for Follicular Communication.

Cells·2026

相关实验视频

Updated: Jun 14, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.1K

通过蛋白质基因组学来表型瘤异质性:研究模型和挑战

Diletta Piana1,2, Federica Iavarone1,2, Elisa De Paolis2,3

  • 1Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

International journal of molecular sciences
|August 29, 2024
PubMed
概括

瘤异质性,瘤内部和瘤之间的多样性,需要先进的方法,如蛋白质基因组学. 这种方法整合了基因组学和蛋白质组学,以揭示分子和表型特征,以便更好地诊断和治疗.

关键词:
癌症 癌症 癌症 癌症 癌症个性化医疗是个性化的医疗.蛋白质基因组学蛋白质组学 蛋白质组学

更多相关视频

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

631
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

11.9K

相关实验视频

Last Updated: Jun 14, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.1K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

631
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

11.9K

科学领域:

  • 在瘤学瘤学.
  • 基因组学就是基因组学.
  • 蛋白质组学是指蛋白质组学.
  • 生物标志物发现发现

背景情况:

  • 瘤异质性,包括瘤间和瘤内变异,呈现出不同的细胞形态和治疗反应.
  • 了解瘤异质性对于确定用于诊断和治疗进步的瘤特异性机制至关重要.
  • 多学科的方法对于描述复杂的瘤特征至关重要.

研究的目的:

  • 审查蛋白质基因组学在特征瘤表型方面的影响.
  • 突出临床和临床前模型中蛋白质基因组学的挑战和局限性.
  • 探索蛋白质基因组学在识别治疗生物标记物的潜力.

主要方法:

  • 蛋白质基因组学集成了基因组学 (下一代测序) 和蛋白质组学 (质谱学).
  • 这种多学科的方法提供了关于瘤异质性的全面观点.
  • 分析侧重于分子变化和表型特征.

主要成果:

  • 蛋白质基因组学通过组合基因组学数据,提供了关于瘤异质性的全面观点.
  • 它揭示了与瘤亚型相关的分子变化和表型特征.
  • 通过这种综合方法,可以识别潜在的治疗生物标志物.

结论:

  • 蛋白质基因组学是理解瘤异质性及其表型特征的强大工具.
  • 尽管取得了进展,但敏感性,特异性和研究模型方面的挑战仍然存在.
  • 需要进一步开发,以充分利用蛋白质基因组学用于癌症诊断和治疗.