Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

30.3K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.3K
What are Lipids?01:31

What are Lipids?

7.5K
Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
7.5K
Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

3.3K
Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
3.3K
Types of Hormones01:21

Types of Hormones

3.0K
Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
3.0K
Structure of Conjugated Dienes01:16

Structure of Conjugated Dienes

4.9K
Introduction
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
4.9K
Structure of Lipids03:38

Structure of Lipids

9.5K
9.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABA<sub>A</sub> Receptor Agonism and NMDA Receptor Inhibition.

bioRxiv : the preprint server for biology·2026
Same author

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Nature·2026
Same author

Structure-activity relationships of steroid and sterol neuromodulators on inflammatory markers in a murine microglial cell line.

The Journal of steroid biochemistry and molecular biology·2026
Same author

Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters.

Analytical chemistry·2026
Same author

The orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport.

bioRxiv : the preprint server for biology·2026
Same author

Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1.

Nature communications·2026

相关实验视频

Updated: Jun 14, 2025

Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster
12:10

Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster

Published on: April 14, 2017

10.4K

5β-二类固醇:形成和特性

Trevor M Penning1, Douglas F Covey2,3

  • 1Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19061, USA.

International journal of molecular sciences
|August 29, 2024
PubMed
概括

类固醇5β-减少酶 (AKR1D1) 缺乏导致代谢错误和胆酸缺乏. 它的5β-二类固醇产物调节核受体和离子通道,影响各种生理过程.

关键词:
胆汁酸 胆汁酸 胆汁酸法恩索伊德的X受体是什么神经活性类固醇的神经活性类固醇.怀孕前的X受体受体平滑肌肉放松放松的方法托科利西斯 (tocolysis) 是一种溶解过程.

更多相关视频

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

16.0K
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
12:04

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Published on: August 14, 2012

28.8K

相关实验视频

Last Updated: Jun 14, 2025

Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster
12:10

Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster

Published on: April 14, 2017

10.4K
Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

16.0K
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
12:04

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Published on: August 14, 2012

28.8K

科学领域:

  • 生物化学 生物化学
  • 内分泌学 在内分泌学.
  • 代谢障碍 代谢障碍 代谢障碍

背景情况:

  • 5β-二类固醇是通过类固醇5β-减少酶 (AKR1D1) 从Δ4-3-类固醇合成的.
  • AKR1D1的遗传缺陷与类固醇5α-减少酶的遗传缺陷相似,导致像胆酸缺陷这样的代谢障碍.
  • 5β-二类固醇,像它们的5α-对应物一样,具有超出简单前体的生物活性.

研究的目的:

  • 审查5β-二类固醇的多样化生物功能.
  • 突出AKR1D1产生的代谢产物的调节作用.
  • 为了识别5β-二类固醇研究领域的知识差距.

主要方法:

  • 关于类固醇5β-减少酶 (AKR1D1) 和其产品的研究文献综述.
  • 分析了各种5β-二类固醇类的已知功能 (糖皮质类固醇,怀孕,安德罗斯坦,胆酸).
  • 与相关的类固醇代谢产物比较5β-二类固醇的活性.

主要成果:

  • 5β-二类固醇调节联体对核受体的接入,并作为核受体和膜结合受体的联体.
  • 具体的例子包括5β-二葡萄糖皮质体,使葡萄糖皮质体受体失活,5β-孕妇在GABA和NMDA受体上起作用,5β-安德罗斯坦会导致血管扩张.
  • 通过这种途径产生的胆汁酸作为FXR的连接体,影响胆固醇稳态.

结论:

  • 5β-二类固醇表现出显著的生物活性,通常通过各种机制在膜水平.
  • AKR1D1在调节类固醇激素活性和代谢途径方面发挥着至关重要的作用.
  • 需要进一步的研究,以充分阐明5β-二类固醇的功能和影响.