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马特林通过NOX2抑制了由诱导的SV-HUC-1细胞恶性转变

Lanfei Wang^1,2,3, Nianfeng Qiu^1,2,3, Suyuan Tong^1,2,3

¹Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang 110122, China.

International journal of molecular sciences

|August 29, 2024

概括

马特林通过减少NADPH氧化酶2 (NOX2) 和NLRP3炎症酶激活来抑制诱导的膀癌. 这项研究揭示了孕妇.

科学领域:

毒理学和致癌的产生.
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

是一种与膀癌相关的人类致癌物,但机制尚不清楚.
NADPH氧化酶2 (NOX2) 促进瘤的发展,并与NLRP3炎症酶激活有关.
马特林显示出潜在的治疗效果,但其在引起的膀癌中的作用尚未被探索.

研究的目的:

通过NOX2.2,研究马林是否可以通过NOX2抑制尿皮细胞中诱导的恶性转变.
阐明NOX2和NLRP3炎症酶在引起的膀上皮细胞变化中的作用.

主要方法:

亚慢性化 (NaAsO2) 暴露的老鼠模型.
长期接触NaAsO2的细胞模型.
评估细胞增殖,迁移,血管新生,ROS,NOX2和NLRP3炎症酶表达与没有母体治疗.

主要成果:

暴露增加了细胞增殖,迁移和血管生成,并增加了ROS,NOX2和NLRP3炎症酶的表达.
在体内和体外,母体注射显著逆转了对膀上皮细胞的有害影响.
孕妇下调的增殖,迁移,血管生成,NOX2和NLRP3炎症酶表达.

结论:

马特林抑制了诱导的膀上皮细胞转化.
马特林的机制包括降低NOX2水平和抑制NOX2-NLRP3炎症酶途径.
马特林显示出作为治疗诱导的膀癌的治疗剂的潜力.

关键词:

在NADPH氧化酶2中.在NLRP3中,NLRP3是NLRP3中的一个.亚是一种.膀癌:膀癌是一种癌症.孕妇 (matrine) 是一个母亲.

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