在患有多发性硬化症的患者中,外周血液细胞中的矿物甲基皮质受体信号传递
Franziska Küstermann1, Kathy Busse1,2, Johannes Orthgieß1
1Klinik und Poliklinik für Neurologie, University of Leipzig, 04103 Leipzig, Germany.
International journal of molecular sciences
|August 29, 2024
概括
多发性硬化症 (MS) 与神经内分泌功能的改变有关,特别是患者的矿物质皮质体受体 (MR) 和OTUD1表达的降低. 这一发现可能有助于指导MS疾病修饰疗法的治疗选择.
科学领域:
- 神经内分泌学神经内分泌学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 多发性硬化症 (MS) 涉及神经内分泌失调,特别是下丘脑-垂体-上腺轴.
- 以前的研究表明,MS患者的葡萄糖皮质体受体 (GR) 和矿物质皮质体受体 (MR) 表达减少.
- 目前用于MS的疾病修饰治疗 (DMT) 缺乏可靠的生物标志物来选择治疗或监测反应.
研究的目的:
- 调查矿物质皮质体受体 (MR) 信号在多发性硬化症 (MS) 中的作用.
- 确定潜在的生物标志物,以评估多发性硬化症的病程和治疗反应.
- 探索MR信号与当前的MS疗法之间的关系.
主要方法:
- 利用来自志愿者的外周血液单核细胞 (PBMC) 进行细胞培养和基因表达分析 (微阵列,qPCR).
- 识别了OTUD1mRNA表达作为MR信号传递的代表性标记.
- 从MS患者和健康对照的全血样本中量化MR和OTUD1表达水平.
主要成果:
- 119名多发性硬化症 (或CIS) 患者的MR和OTUD1表达显著降低,与42名对照组相比.
- 在接受fingolimod治疗的MS患者中,MR表达特别减少.
- 基因表达模式表明MR信号与某些DMT的治疗作用之间存在联系.
结论:
- 在MS中,MR和OTUD1的表达水平可以作为补充的神经内分泌生物标志物.
- 这些标记物可能有助于在临床决策过程中选择和监测多发性硬化症治疗方法.
- 需要进一步验证,以确认MR和OTUD1在临床实践中的实用性.
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