奇孔古尼亚和玛雅罗病毒诱导慢性骨肌肉缩,由亲炎和氧化反应触发
Mariana Oliveira Lopes da Silva1, Camila Menezes Figueiredo1, Rômulo Leão Silva Neris1
1Department of Virology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
奇孔古尼亚和玛雅罗病毒会导致长期的肌肉疼痛. 病毒RNA在肌肉中持续存在,即使感染消失后也会导致缩,突出显示潜在的治疗点.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 奇孔古尼亚 (CHIKV) 和玛雅罗 (MAYV) 是致关节性阿尔法病毒,导致持续性炎症性肌关节疾病.
- 对CHIKV和MAYV对骨肌肉 (SkM) 和症状持续性的长期影响尚不清楚.
- 骨肌肉在这些病毒感染的发病过程中发挥着关键作用.
研究的目的:
- 研究CHIKV和MAYV感染对骨肌肉组成,结构和修复的时间影响.
- 阐明阿尔法病毒感染后长期骨肌肉缩背后的机制.
- 确定潜在的治疗点,以减轻CHIKV和MAYV诱导的肌肉病理.
主要方法:
- 在野生型小鼠模型中对CHIKV和MAYV复制的时间调查.
- 利用分子,形态,核磁共振成像和组织学分析.
- 评估病毒RNA持久性,肌肉缩标志物 (MuRF1,Atrogin-1),炎症调解物 (TNF) 和氧化应激 (Nrf2).
主要成果:
- 病毒复制和炎症导致迅速的肌肉质量损失和通过MuRF1和Atrogin-1上调调节减少纤维横截面积.
- 骨肌缩持续30天感染后,尽管减少了炎症和病毒清除.
- 基因组CHIKV和MAYVRNAs在感染后期的SkM中被检测到,具有升高的化学激素和抗炎性细胞激素表达.
- TNF 中和和 Nrf2 激活 (单甲基 fumarate) 减少了缩和增加了体重.
结论:
- 关节性阿尔法病毒感染可以长期影响骨肌肉的组成,并损害肌肉修复机制.
- 持续的病毒RNA和炎症调解剂有助于长期肌肉缩.
- 准TNF和氧化应激通路为阿尔法病毒诱导的肌肉病症提供了潜在的治疗策略.
更多相关视频
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
04:01Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
Published on: June 14, 2024
相关概念视频
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Cross-bridge Cycle
Satellite Stem Cells and Muscular Dystrophy
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
