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由于暴露于而引起的巨巨的心电图的形态学变化
Lorena Meirelis do Nascimento1, Murilo Farias Dos Santos1, Clarissa Araújo da Paz1
1Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences-ICB/UFPA, Belém 66077-830, PA, Brazil.
International journal of molecular sciences
|August 29, 2024
概括
接触会对鱼类的心脏功能产生负面影响,降低心脏活动,并延长像P-Q和S-T这样的间隔,增加暴露时间. 这项研究突出了Tambaqui鱼中中毒的心脏风险.
科学领域:
- 环境毒理学环境毒理学
- 心血管生理学心血管生理学
- 水生生物学 水生生物学
背景情况:
- (Mn) 是一种必不可少的元素,但在高剂量下是有毒的,会导致带有神经,心脏和肺部影响的化.
- 工业活动将释放到环境中,对水生生态系统构成风险.
- 了解鱼类中的毒性对于环境健康评估至关重要.
研究的目的:
- 为了评估中毒对坦巴基鱼 (Colossoma macropomum) 的心脏影响.
- 为了确定暴露时间和心脏功能变化之间的关系.
- 评估鱼类心血管系统对暴露的敏感性.
主要方法:
- 将Tambaqui鱼暴露在固定度 (4 mg/mL) 的中,长达96小时.
- 监测心电图 (ECG) 来记录心率,R-R间隔,P-Q间隔,QRS持续时间和S-T间隔.
- 对不同暴露时间 (24,48,72,96小时) 的心脏参数进行比较.
主要成果:
- 随着长时间的暴露,鱼类的心脏活动显著下降.
- 电心电图的P-Q和S-T间隔随着暴露时间的延长而显著增加.
- 这些发现表明由于接触而导致循环平衡的破坏.
结论:
- 中毒会损害科洛索马巨型的心脏功能.
- 暴露时间是对心脏影响严重性的关键因素.
- 这项研究表明,对鱼类心血管健康的有害影响.
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