激活G蛋白合雌激素受体 (GPER) 通过PI3K/NOS/NO通路负面调节心脏刺激-收缩合 (ECC)

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Leandro A Diaz-Zegarra1, María S Espejo1,2, Alejandro M Ibañez1

  • 1Centro de Investigaciones Cardiovasculares "Dr. Horacio E. Cingolani", Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, La Plata 1900, Buenos Aires, Argentina.

International journal of molecular sciences
|August 29, 2024
PubMed
概括

在老鼠心脏细胞中,G蛋白结合雌激素受体 (GPER) 的激活减少了过渡和L型电流,表明了负面的内效应. 这种机制涉及酸-3-酶/氧化合成酶/氧化通路.

关键词:
与G蛋白结合的雌激素受体 (GPER)目前的L型电流威斯塔尔老鼠是什么意思过渡性的过渡性.这是心肌细胞 (cardiomyocytes).细胞缩短导致细胞缩短.

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