益生菌在炎症引起的结肠直肠癌中的抗氧化作用
Sevag Hamamah1,2, Andrei Lobiuc3, Mihai Covasa1,3
1Department of Basic Medical Sciences, College of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.
International journal of molecular sciences
|August 29, 2024
概括
肠道微生物通过活性氧物种 (ROS) 和炎症影响结肠直肠癌 (CRC). 益生菌可以通过调节这些因素,为CRC提供新的治疗策略.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 肠道微生物失调,活性氧物种 (ROS) 和炎症都与CRC的发展有关.
- 细菌代谢物可以影响氧化应激和炎症,影响CRC的病变发生.
研究的目的:
- 审查将肠道微生物群转移和代谢物与ROS和CRC炎症联系在一起的机制.
- 探索益生菌在调节ROS介导信号通路以缓解CRC中的作用.
- 根据肠道微生物群和氧化应激相互作用,突出显示CRC的潜在治疗途径.
主要方法:
- 对肠道微生物群,ROS,炎症和CRC研究的文献综述.
- 细菌代谢物 (SCFA,胆酸,TMAO) 的分析及其对氧化应激的影响.
- 检查益生菌对ROS介导信号通路 (Nrf2-Keap1,NF-κB,NLRP3) 的作用.
主要成果:
- 肠道微生物群的组成和代谢物显著影响ROS水平和炎症,影响CRC的发病和进展.
- 益生菌可以调节关键信号通路,影响氧化状态和炎症,以潜在地减轻CRC.
- 特定的代谢物,如短链脂肪酸 (SCFA),二次胆汁酸和三甲基胺-N-氧化物 (TMAO) 起着至关重要的作用.
结论:
- 了解肠道微生物群在氧化应激中的作用对于预防和治疗CRC至关重要.
- 益生菌通过调节ROS和炎症,代表了对CRC的有希望的辅助疗法.
- 准肠道微生物群和氧化应激通路为CRC免疫疗法和预防提供了新的策略.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
130
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
130
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
328
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
328
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
358
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
358


