在SARS-CoV-2感染中出现急性后续和线粒体异常
Charles Ward1, Beata Schlichtholz1
1Department of Biochemistry, Gdańsk University of Medicine, 80-210 Gdańsk, Poland.
International journal of molecular sciences
|August 29, 2024
概括
本综述探讨了SARS-CoV-2感染如何影响细胞代谢,线粒体功能和先天免疫力,可能解释急性后续症 (PASC) 和病毒持续性.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 细胞代谢和线粒体生物学
- 计算生物学和生物信息学
背景情况:
- 感染SARS-CoV-2可能导致长期健康问题,称为SARS-CoV-2感染 (PASC) 后急性后果.
- 新兴研究表明,在PASC中,病毒持久性,线粒体功能障碍和异常的先天免疫反应之间存在联系.
- 奥米克技术和计算方法的进步使得这些复杂的相互作用能够得到详细的研究.
研究的目的:
- 审查和综合有关SARS-CoV-2感染,病毒持久性,线粒体功能,先天免疫力和细胞代谢之间的联系的当前知识.
- 突出蛋白质组,代谢组和计算生物学方法在理解PASC病原学的作用.
- 为了探索这种假设,线粒体对病毒遗传物质的隔离有助于病毒的持久性.
主要方法:
- 对研究SARS-CoV-2感染和PASC的综合文献综述.
- 分析利用蛋白质组,代谢组和计算生物学技术的研究.
- 专注于检查病毒与宿主相互作用的研究,特别是涉及病毒基因/蛋白质,线粒体和天生的免疫系统.
主要成果:
- 感染SARS-CoV-2导致细胞代谢,自和线粒体功能发生显著变化.
- 异常的先天免疫反应与PASC的发病有关.
- 计算生物学和机器学习有助于预测与SARS-CoV-2感染相关的病毒宿主相互作用.
结论:
- 线粒体功能障碍和细胞代谢的改变是SARS-CoV-2病变和PASC的关键因素.
- 天生的免疫系统在宿主对SARS-CoV-2感染的反应中发挥着关键作用.
- 病毒持久性可能与病毒遗传物质的线粒体隔离有关,需要进一步调查.
相关概念视频
01:45Mitochondrial Membranes
9.3K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
9.3K
01:28The Inner Mitochondrial Membrane
3.3K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria. In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.3K
01:46Electron Transport Chain: Complex I and II
12.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.3K
01:41The Supercomplexes in the Crista Membrane
2.5K
The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
2.5K
01:24Muscle Recovery and Fatigue
2.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.0K