癌症患者中血栓微血管病变的现象
Alexander Vorobev1, Victoria Bitsadze1, Fidan Yagubova1
1Department of Obstetrics, Gynecology and Perinatal Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str. 8-2, 119991 Moscow, Russia.
血栓式微血管病 (TMA) 涉及小血管中的血栓,导致器官损伤. 及时诊断和治疗,包括解决ADAMTS13缺乏症等潜在原因,对于更好的结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 病理生理学 病理生理学
- 血管生物学 血管生物学
背景情况:
- 血栓性微血管病变 (TMA) 是一组由微血管血栓和器官损伤为特征的疾病.
- TMA综合征包括血栓性血栓细胞性紫外线 (TTP) 和血溶性尿素综合征 (HUS).
- 血栓炎症和内皮损伤是TMA病变发生的关键因素.
研究的目的:
- 审查血栓性微血管病变 (TMA) 的发病,原因和治疗方法.
- 突出ADAMTS13缺陷在原发性TMA和与癌症相关的TMA中的作用.
- 讨论药物诱导的TMA (DITMA) 和TMA在严重的COVID-19中.
主要方法:
- 对TMA病原,临床表现和治疗策略的文献综述.
- 分析ADAMTS13,·威尔布兰德因子 (VWF) 和血栓炎症的作用.
- 检查特定的TMA亚型和相关条件.
主要成果:
- 像TTP一样,初级TMA通常与ADAMTS13活性降低有关.
- 癌症和化疗可以降低ADAMTS13并增加VWF,增加血栓形成的风险.
- 与严重的COVID-19相关的DITMA和TMA存在复杂的挑战.
结论:
- 有效的TMA管理需要确定潜在的原因和向治疗.
- 抑制补充激活和支持性护理至关重要.
- 及时诊断和像等离子体酶这样的干预措施可以改善患者的治疗结果.
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