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母亲空气污染暴露和婴儿肺功能之间的关联是由对氧化应激的遗传倾向所改变的

Dwan Vilcins¹, Wen Ray Lee¹, Cindy Pham^2,3

¹Child Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia.

Children (Basel, Switzerland)

|August 29, 2024

概括

产前暴露于二氧化 (NO2) 空气污染与患有氧化应激 (OS) 的遗传倾向的婴儿的婴儿肺功能降低有关. 这项研究强调了空气污染的特定遗传风险因素.

科学领域:

环境健康环境健康
儿科呼吸系统医学儿科呼吸系统医学
遗传学和表观遗传学

背景情况:

空气污染对呼吸系统健康构成重大风险,特别是在发育中的胎儿身上.
由于正在进行的器官发育,儿童特别容易受到产前空气污染的暴露.
氧化应激 (OS) 和炎症是受到空气污染影响的关键生物通路.

研究的目的:

研究孕妇在怀孕期间暴露于环境空气污染对婴儿氧化应激,炎症和肺功能的影响.
确定对氧化应激的遗传倾向是否会改变产前空气污染对婴儿呼吸系统健康的影响.

主要方法:

利用巴沃恩婴儿研究 (n=314) 的数据来评估产前暴露于NO2和PM2.5.5.的情况.
在4周使用多次呼吸洗测量婴儿肺功能.
评估了OS和炎症的产前生物标志物 (GlycA,OS生物标志物),并计算了OS (gPFSox) 的遗传途径得分.

主要成果:

没有发现母亲空气污染暴露与婴儿肺功能或产前OS/炎症标志物之间的关联.
在产前暴露于NO2的具有OS遗传倾向的婴儿显示功能残留容量 (FRC) 显著降低,肺清除指数 (LCI) 高.

结论:

产前暴露于环境二氧化 (NO2) 与婴儿肺功能受损 (较低的FRC,较高的LCI) 相关,这些婴儿具有对氧化应激的遗传敏感性.
母亲和带血炎症和OS生物标志物与产前空气污染暴露无关.

关键词:

空气污染物的空气污染物.儿童的健康问题环境健康环境健康肺功能肺功能肺功能二氧化是什么?二氧化是什么?氧化应激是一种氧化应激.

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