应用Galenic策略开发胃耐药的Omeprazole配方用于儿科
Khadija Rouaz-El-Hajoui1, Encarnación García-Montoya1,2, Marc Suñé-Pou1,2
1Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
Children (Basel, Switzerland)
|August 29, 2024
概括
开发一个稳定的肠道配方的儿科用梅是至关重要的. 湿颗粒化实现了44%的胃抗性,显示出这一必需的质子抑制剂的医院药房化合物的前景.
科学领域:
- 儿科药物治疗药物治疗.
- 制药配方科学 制药配方科学
背景情况:
- 奥梅普拉对于治疗儿科胃肠道疾病至关重要.
- 挑战包括奥梅普拉的酸性不稳定性和复杂性质.
- 医院药房需要可访问的儿科配方.
研究的目的:
- 开发一款用于儿科的肠道奥梅普拉制剂.
- 设计一个合并配方,适用于没有工业设备的医院药房.
- 增强奥梅普拉的稳定性和胃抵抗性.
主要方法:
- 应用的化策略:脱盐,离子凝和矩阵颗粒化.
- 在酸性环境中研究了欧梅普拉的不稳定性.
- 实验的确定的控制条件和参数.
主要成果:
- 湿颗粒表现最有前途,达到44%的胃抗性.
- 离子凝和化技术没有产生令人满意的结果.
- 确定湿颗粒作为肠道涂层的可行策略.
结论:
- 替代的配方策略是必要的,以保持奥梅普拉的稳定性.
- 优质的儿科配方需要多学科的方法.
- 需要进一步开发以满足胃抵抗标准.
相关概念视频
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