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放射治疗在低进展性乳腺癌中的结果
Fabio Marazzi1, Valeria Masiello1, Armando Orlandi2
1Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, 00168 Rome, Italy.
Journal of personalized medicine
|August 29, 2024
概括
放射治疗 (RT) 可以改善转移性乳腺癌 (mBC) 患者的 limited进展的结果. 较高的RT生物有效剂量 (BED) 与治疗后更长的无进展生存时间相关.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 寡进性转移性乳腺癌 (mBC) 对于局部控制来说是一个挑战.
- 放射治疗 (RT) 正在作为一种在全身治疗期间管理有限疾病进展的策略而被探索.
研究的目的:
- 评估RT在患有寡进性mBC的患者中的疗效和结果.
- 在这个人群中确定影响RT后无进展生存的因素.
主要方法:
- 在全身治疗期间 (2014-2021) 接受RT的59名mBC患者的回顾性分析.
- 终点包括放射治疗后无进展生存率 (PFS-AR),3个月后系统性治疗中止率 (RDT) 和整体生存率 (OS).
- 多变量考克斯回归分析用于确定PFS-AR的显著预测因素,包括生物有效剂量 (BED).
主要成果:
- 中位数PFS-AR为13个月;三个月后的RDT为3%.
- 在早期和晚期的全身疗法之间,PFS-AR的显著差异被观察到 (p=0.03).
- 较高的BED (α/β = 4 > 100 Gy) 是改善PFS-AR的唯一显著预测因素 (p=0.0017);中位数OS为24.4个月.
结论:
- 这是第一个报告50多名接受RT治疗的寡进性mBC患者的结果的研究.
- PFS-AR与全身疗法线的数量和RT的BED显著相关.
- RT在管理寡进性mBC方面显示出潜在的益处,而BED是治疗成功的关键因素.
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