在不活跃的坟墓轨道病变中,亚临床的眼动性功能障碍和眼外肌肉变化
Filippo Lixi1, Alberto Cuccu1, Giuseppe Giannaccare1
1Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.
Journal of personalized medicine
|August 29, 2024
概括
没有活动的坟墓.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 格雷夫斯轨道病 (GO) 可以导致眼外肌肉 (EMs) 的结构和功能变化.
- 评估不活跃GO的这些变化对于了解疾病进展和管理至关重要.
- 亚临床EOM功能障碍可能会持续,即使GO在临床上不活跃.
研究的目的:
- 研究非活跃格雷夫斯病 (GD) 和GO患者的EMS的结构和功能变化.
- 评估红色过器测试 (RFT) 在检测隐性双眼视和亚临床EOM功能障碍方面的有效性.
- 为了将EOM变化与非活性GO的临床参数相关联.
主要方法:
- 67名不活性GO患者接受了临床评估,甲状腺功能测试和自身抗体水平测量.
- 轨道超声波 (US) 用于评估EOM形态.
- 评估了眼睛的运动性,并根据RFT结果对患者进行了分层 (潜在双眼视的阳性或阴性).
主要成果:
- 近一半 (49.25%) 的非活性GO患者在RFT上表现出隐性双眼视,并未通过标准测试检测到.
- 在RFT阳性和RFT阴性组之间,在年龄,疾病持续时间,抬头视线中的IOP升高和中间直肠肌肉厚度方面发现了显著的差异.
- 在甲状腺状况,自身抗体水平,CAS,外眼或侧直肠厚度方面没有发现显著差异.
结论:
- 亚临床外眼肌肉功能障碍和形态变化存在于非活跃的Graves轨道病变中.
- 红色镜测试是检测隐性双眼视和识别微妙的眼动性问题的宝贵工具.
- 结合功能测试 (RFT) 和成像的综合评估对于早期GO异常检测和管理至关重要.
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