基于炎症的预后标志物与被送往重症监护室的患者的死亡率之间的关联
Ah Ran Oh1, Jeong-Am Ryu2,3, Seung Joo Lee1
1Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Diagnostics (Basel, Switzerland)
|August 29, 2024
概括
与SOFA得分相比,C反应蛋白 (CRP) 与白蛋白 (CAR) 的比率更好地预测了ICU患者的长期死亡率. CAR,NLR和mGPS是ICU入院后死亡率的独立风险因素.
科学领域:
- 关键护理医学 关键护理医学
- 生物标志物 生物标志物
- 预测指标的预测指标
背景情况:
- 在重症监护室 (ICU) 评估死亡风险对于患者管理至关重要.
- 像SOFA这样的传统分数需要经常更新和复杂的计算.
- 更简单的炎症标志物可能提供预后价值.
研究的目的:
- 为了比较C反应蛋白 (CRP) 与白蛋白比率 (CAR),中性粒细胞与淋巴细胞比率 (NLR) 和修改格拉斯哥预后得分 (mGPS) 与序列器官衰竭评估 (SOFA) 得分的预后性能.
- 为了评估这些标志物来预测28天和1年的成年ICU患者的死亡率.
主要方法:
- 从2013年6月到2022年5月,对53877名成年ICU入院者的回顾性分析.
- 使用多变量逻辑回归和接收器操作特征 (ROC) 曲线分析.
- 评估了CAR,NLR,mGPS和SOFA得分的预测准确性.
主要成果:
- 所有测试得分 (SOFA,CAR,NLR,mGPS) 都是28天和1年死亡率的独立风险因素.
- 与NLR和mGPS相比,CAR显示出更高的可预测性.
- 对于1年死亡率,CAR的预测能力明显超过了SOFA得分.
结论:
- CAR,NLR和mGPS是ICU入院后死亡率的有价值的独立预测指标.
- 与SOFA得分相比,CAR显示了对长期死亡率的增强预测能力.
- 在ICU入院时进行CAR评估是一种潜在的可行方法,用于预测患者的长期结果.
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