小肠囊内镜在复杂外周疾病的诊断算法中的作用
Irit Avni-Biron1,2, Ervin Toth3,4, Jacob E Ollech1,2
1Division of Gastroenterology, Rabin Medical Center, Petah Tikva 4941492, Israel.
Diagnostics (Basel, Switzerland)
|August 29, 2024
概括
小肠囊内镜 (SBCE) 有助于诊断克罗恩病 (CD) 在四分之一的患者有复杂的周围病 (cPD) 在最初的负面检查后. 便calprotectin具有较低的预测价值,支持SBCE的考虑.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病是什么
- 诊断成像 诊断成像 诊断成像
背景情况:
- 复杂的近部疾病 (cPD) 可能是克罗恩病 (CD) 的首要表现.
- 小肠囊内镜 (SBCE) 在诊断cPD中的实用性仍然不确定.
- 这项研究调查了SBCE在诊断CD中的作用,当标准检查结果不确定时.
研究的目的:
- 评估SBCE在患有cPD的患者中的诊断价值.
- 为了确定SBCE是否可以在负面标准调查后识别克罗恩病 (CD).
- 评估便calprotectin (FC) 水平与SBCE发现之间的相关性.
主要方法:
- 一个多中心,回顾性,横截面研究.
- 包括患有慢性慢性病和负面标准治疗 (骨髓结肠镜检查,横截面成像) 的患者,他们接受了SBCE.
- 分析了人口统计数据,生物标志物和易斯得分 (LS);LS ≥135表示CD的阳性SBCE.
主要成果:
- 研究了91名患有cPD的患者 (71.4%是男性,平均年龄为37岁).
- 在26.4%的患者中,SBCE给出了CD的正确诊断.
- 便calprotectin (FC) 与LS相关 (r=0.81,p<0.001),但对于排除小肠CD的敏感性和NPV很低.
结论:
- 在超过四分之一的CPD患者中,SBCE有助于诊断CD,这些患者最初的治疗结果为负.
- FC水平与炎症严重程度相关,但具有有限的负预测值.
- 在cPD患者中诊断CD的SBCE是一个有价值的工具,即使标准检查结果是负面的.
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