分析同胞性运行的分析揭示了德国棕牛的选择模式
Anna Wirth1, Jürgen Duda2, Reiner Emmerling3
1Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.
Genes
|August 29, 2024
概括
德国棕牛的基因组内生育与美国棕牛的瑞士基因侵入和寿命减少有关. 较低的近亲繁殖,以同卵性 (ROH) 的运行来衡量,与增加的生存率和影响健康和生产的特定基因区域有关.
科学领域:
- 动物遗传学动物遗传学
- 量化遗传学 量化遗传学
- 基因组学就是基因组学.
背景情况:
- 德国棕色牛表现出不断增加的近亲繁殖系数和近亲繁殖抑郁症的长寿.
- 美国棕色瑞士基因在德国棕色种群中的比例正在上升,这可能会影响遗传多样性和表现.
研究的目的:
- 为了分析德国棕牛的同卵性性 (ROH) 运行.
- 调查ROH与美国棕色瑞士基因比例和牛在更高的哺乳期生存的关联.
主要方法:
- 来自2364头德国棕牛的基因型数据,使用49693个自体SNP.
- 识别和描述ROH,计算基因组内生系数 (FROH).
- 在ROH,近亲繁殖系数,美国棕色瑞士基因比例和生存率之间的相关性分析.
主要成果:
- 每个人平均ROH为35.996±7.498,平均长度为8.323±1.181Mb;基因组内生育 (FROH) 为0.122±0.032.
- 在动物中观察到低基因组内生 (FROH,FROH>4,FROH>8,FIS) 的动物<60%的美国棕色瑞士基因与>80%相比.
- 幸存到更高哺乳期的奶牛表现出较低的基因组内生育,与更少和更短的ROH有关. 在BTA 6和BTA 7发现了与长寿,健康和牛奶生产相关的显著ROH岛屿.
结论:
- 基因组内生,特别是较长的ROH,与德国棕牛的生存率降低有关.
- 美国棕色瑞士基因的比例影响了基因组内生繁殖水平.
- 育种策略应该旨在减少基因组内生育,并平衡生产,强度和寿命特征.
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