肥胖和结肠直肠癌:一个叙事审查
Bárbara Cristina Jardim Miranda1,2, Francisco Tustumi3,4, Eric Toshiyuki Nakamura3
1Department of Surgery, Instituto de Assistência Médica ao Servidor Público Estadual-IAMSPE, Sao Paulo 04029-000, SP, Brazil.
Medicina (Kaunas, Lithuania)
|August 29, 2024
概括
肥胖症显著增加结直肠癌 (CRC) 的风险,并使治疗复杂化. 体重管理策略对于降低CRC发病率和改善患者治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 代谢综合征是代谢综合征的一种.
背景情况:
- 结肠直肠癌 (CRC) 是全球领先的癌症,发病率不断上升,特别是在年轻人群中.
- 生活方式因素,包括久坐不动,饮食不良和肥胖,与CRC风险增加有关.
- 肥胖影响全球近40%的人口,并提高了几种癌症的死亡风险.
研究的目的:
- 审查关于肥胖和结直肠癌 (CRC) 之间的关联的科学文献.
- 探索将肥胖与CRC联系在一起的病理生理机制.
- 检查肥胖的CRC患者的治疗策略和挑战.
主要方法:
- 进行了叙事文学评论.
- 审查的重点是病理生理机制,治疗策略和挑战.
- 分析了确定肥胖和CRC关系的关键研究.
主要成果:
- 肥胖和CRC风险增加之间存在明显的因果关系,特别是病态肥胖.
- 部脂肪组织分泌有炎症的细胞因子 (例如TNF-alpha,IL-6),促进与癌症相关的慢性炎症.
- 肥胖症复杂化了CRC治疗,降低了疗效,增加了不良事件的风险.
结论:
- 肥胖是结直肠癌 (CRC) 发展和进展的关键因素.
- 体重管理干预措施,包括饮食改变和减肥手术,对于预防CRC和改善治疗结果至关重要.
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