预测Helicobacter pylori相关消化不良症状根除疗法的有效性的因素
Kohei Yasuda1, Daisuke Chinda2, Tadashi Shimoyama3
1Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Life (Basel, Switzerland)
|August 29, 2024
概括
血清pepsinogen水平,特别是pepsinogen I/II比率,可以预测Helicobacter pylori根除腹的成功. 低于2.3的比率和吸烟习惯表明症状改善的可能性较低.
科学领域:
- 胃肠病学 胃肠病学
- 临床诊断 临床诊断 临床诊断
- 微生物学 微生物学
背景情况:
- 区分功能性消化不良症与Helicobacter pylori相关的消化不良症的预治疗是具有挑战性的.
- 根除Helicobacter pylori是一种关键的治疗方法,但很难预测治疗失败症状的成功.
- 血清pepsinogen水平可以提供关于胃粘膜状况的见解,并预测治疗结果.
研究的目的:
- 研究根除前血清pepsinogen水平和H. pylori根除后消化不良症状的改善之间的关联.
- 评估血清素水平的预测价值以及消化不良后消化不良结果的其他因素.
主要方法:
- 接受H. pylori根除的患者被评估是否有消化不良症状的变化.
- 在治疗前测量了血清pepsinogen I和II水平.
- 使用统计分析,包括多变量逻辑回归来确定治疗反应的预测因素.
主要成果:
- 在响应者 (3.4 ± 1.2) 和不响应者 (2.3 ± 1.0) (p = 0.006) 之间观察到素I/II比率的显著差异.
- 确定了2.3的最佳切断点pepsinogen I/II比率.
- 素I/II比≤2.3 (OR 26.1) 和吸烟习惯 (OR 8.10) 是对H. pylori根除无反应的显著预测因素.
结论:
- 素I/II比率是预测H. pylori根除在患有消化不良的患者中有效性的有价值的生物标志物.
- 一个pepsinogen I/II比率≤2.3和吸烟与H. pylori根除后的较差结果有关.
- 这个比率可以帮助识别不太可能从H. pylori根除中受益的患者,指导进一步的管理策略.
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