老化骨肌肉中的线粒体适应:对抵抗运动训练的含义,以治疗皮症
Ilyoung Jeong1, Eun-Jeong Cho1, Jang-Soo Yook2
1Program in Biomedical Science & Engineering, Department of Biomedical Science, Inha University, Incheon 22212, Republic of Korea.
Life (Basel, Switzerland)
|August 29, 2024
概括
抵抗运动训练 (RET) 可以改善老化肌肉中的线粒体功能,对抗肉类. 本综述探讨了RET如何影响老年人的线粒体动力学和健康.
科学领域:
- 老年学是一门学科.
- 骨肌肉生理学 骨肌肉生理学
- 线粒体生物学 线粒体生物学
背景情况:
- 随着年龄的增长而导致肌肉质量和功能丧失的sarcopenia是一个日益严重的全球健康问题.
- 线粒体功能障碍,包括改变的线粒体反应性氧物种 (mtROS),生物发生,动力学和线粒体衰变,是导致肉症的关键因素.
- 虽然有氧运动训练 (AET) 已知对线粒体有好处,但阻力运动训练 (RET) 对老化骨肌肉中的线粒体的影响不太清楚.
研究的目的:
- 审查线粒体动力学和肉症之间的关系.
- 专门研究阻力运动训练 (RET) 对骨肌肉衰老中的线粒体健康的影响.
- 要突出RET调节mtROS的潜力,线粒体生物发生,动力学和线粒细胞衰变.
主要方法:
- 文献综述侧重于研究研究的研究,研究了sarcopenia,骨肌肉衰老,线粒体功能,和运动干预措施.
- 对线粒体反应性氧物种 (mtROS),线粒体生物发生,线粒体动力学和 sarcopenia 中的线粒体衰变作用的现有研究进行分析.
- 关于阻力运动训练 (RET) 对老年人群中这些线粒体参数的影响的综合证据.
主要成果:
- 线粒体功能障碍是萨科佩尼亚发展的关键因素.
- 抵抗运动训练 (RET) 显示出可能对老化骨肌肉中的线粒体健康产生积极影响的潜力.
- RET可能调节mtROS,促进线粒体生物发生,优化线粒体动力学,增强线粒体.
结论:
- 抵抗运动训练 (RET) 通过改善线粒体功能,为缓解缩症提供了一个有希望的干预措施.
- 了解RET和线粒体动态之间的相互作用对于保持老年人骨肌肉健康至关重要.
- 需要进一步的研究,以充分阐明RET影响肉症中线粒体适应的机制.
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