糖尿病视网膜病变的静脉内抗血管治疗:墨西哥现实生活场景体验
Sonia López-Letayf1,2, Oscar Vivanco-Rojas1,2, Valentina Londoño-Angarita2
1Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Av. Universidad 3000, Mexico City 04510, Mexico.
Life (Basel, Switzerland)
|August 29, 2024
概括
内拉尼比祖马布和aflibercept在五年内改善了墨西哥糖尿病眼病患者的视觉敏度和视网膜厚度. 糖尿病黄斑患者的反应较小,突出了治疗细微差别.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病视网膜病变 (DR) 和其并发症,如糖尿病黄斑 (DME),是导致视力丧失的主要原因.
- 内抗血管药物是管理DME和其他DR相关的神经血管疾病的基石治疗.
- 现实世界的有效性数据对于了解不同患者群体的治疗结果至关重要.
研究的目的:
- 评估拉尼比祖马布和阿弗利塞普特在墨西哥糖尿病视网膜病变 (DR),增殖性糖尿病视网膜病变 (PDR) 和糖尿病黄斑 (DME) 患者群体中的5年有效性.
- 在现实环境中评估视觉敏度 (VA) 和视网膜中心厚度 (CRT) 的改善.
- 为了比较 ranibizumab 和 aflibercept 之间的治疗反应,并根据特定的糖尿病眼病情况分析结果.
主要方法:
- 追溯分析了来自294名被诊断患有DR,PDR和/或DME的患者的588只眼睛.
- 患者在5年的时间内接受了拉尼比祖马布和/或阿弗利伯塞普的静脉内注射.
- 用OCT测量视觉敏度 (VA) 和视网膜中心厚度 (CRT) 的变化评估.
主要成果:
- 拉尼比祖马布和阿弗利塞普都在研究人口中显著改善了VA和CRT,无论诊断如何.
- 与其他诊断相比,患有糖尿病黄斑 (DME) 的患者对抗血管原治疗的反应不那么明显 (p < 0.05).
- 观察到的VA的改善与CRT的变化没有一致的相关性,这表明患者报告的结果和OCT测量之间存在脱节.
结论:
- 内抗血管原剂在管理墨西哥人口糖尿病的眼科并发症方面是有效的.
- 虽然治疗可以改善视力和减少视网膜厚度,但它们不能完全逆转大多数患者的结构损伤.
- 患者感知到的视力敏度和眼科医生测量的视网膜厚度可能并不总是相关的,强调需要进行全面评估.
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