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化疗诱导的外周神经病变:最近关于病理生理学和治疗的更新
Marina Mattar1, Florence Umutoni2, Marwa A Hassan1
1Department of Pharmaceutical and Administrative Sciences, Presbyterian College School of Pharmacy, Clinton, SC 29325, USA.
化疗诱导的周围神经病变 (CIPN) 会导致衰弱的神经损伤. 这篇评论探讨了CIPNN的情况.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是某些癌症治疗的显著和持久的不良影响.
- CIPN主要影响感官神经元,导致诸如麻木,刺和四肢疼痛等症状,影响患者的生活质量和治疗坚持.
- 在CIPN背后的精确机制是复杂的,涉及线粒体损伤,离子通道功能障碍,免疫反应和微管破坏.
研究的目的:
- 审查目前对CIPN病理生理学的理解.
- 总结现有和新兴的治疗策略来管理CIPN症状.
- 为CIPN.提供对潜在的药理干预措施的见解.
主要方法:
- 对CIPN.的临床前和临床研究的文献综述.
- 对化疗引起的神经损伤的生理机制研究的分析.
- 综合关于CIPN.目前和研究中的治疗方法的信息.
主要成果:
- 由于缺乏已批准的药理疗法,CIPN存在重大挑战.
- 目前的治疗依赖于使用抗抑郁药,抗氧化剂,抗炎药和离子通道调节剂来缓解症状.
- 有前途的新疗法包括大麻素,西格玛-1受体对抗剂和尼古丁胺胺 рибоoside正在研究中.
结论:
- 对CIPN的有效管理仍然是癌症护理的关键未满足需求.
- 需要采取针对不同病理生理路径的多面性方法.
- 对新型治疗剂的持续研究对于改善CIPN.患者的治疗结果至关重要.
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