提升护肤科学:葡萄提取物封装用于皮肤护理
Maria Leonor Castro1, João Azevedo-Silva1,2, Diana Valente1,2
1CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Molecules (Basel, Switzerland)
|August 29, 2024
概括
葡萄种子提取物,富含生物活性多,被封装成皮肤护理应用的微分散物. 这些稳定提取物表现出抗氧化,抗微生物和抗炎性质,为皮肤健康提供可持续的解决方案.
科学领域:
- 化品科学 化品科学
- 生物技术是生物技术.
- 食品科学 食品科学 食品科学
背景情况:
- 皮肤的完整性对其保护功能至关重要,推动了化学领域的创新.
- 来自植物的化合物,特别是来自葡萄的副产品,为护肤提供了生物活性潜力.
- 像化合物这样的关键分子的不稳定性需要先进的输送系统,如微分散.
研究的目的:
- 为了评估葡萄种子提取物 (GSE) 用于化品应用.
- 为增加稳定性和传递性,将选定的GSE封装到大豆莱西丁微分散剂中.
- 评估封装GSE微分散物的安全性和生物活性.
主要方法:
- 两种葡萄种子提取物 (GSE-Ov和GSE-Sv) 准备并分析了化学成分,抗氧化剂和抗菌活性.
- 最强效的提取物 (GSE-Ov) 被封装在涂的豆微分散剂中.
- 评估了封装效率,体外多释放,粒子特征 (泽塔潜力,直径),细胞安全性 (HaCaT,HDF) 和抗炎作用 (IL-1α).
主要成果:
- GSE-Ov表现出显著的抗氧化活性 (DPPH IC50为0.079 mg mL-1).
- 封装实现了88.8%的效率,在24小时内释放了59.4%的多.
- 微分散在细胞模型中是安全的,并表现出抗炎作用.
结论:
- 葡萄种子提取物可以有效地稳定,并通过皮肤护理的微分散提供.
- 这种方法将葡萄酒行业的副产品提升为功能化品成分.
- 封装GSE有望通过抗氧化和抗炎机制促进皮肤健康.
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