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可见光诱导的迪塞利尼德交联聚合物微粒用于ROS触发的药物输送

Xinfeng Cheng¹, Huixian Li¹, Xiaomeng Sun¹

¹College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.

Molecules (Basel, Switzerland)

|August 29, 2024

概括

研究人员开发了新的可见光交联聚氨微粒,用于控制药物输送. 这些小粒在响应活性氧物种 (ROS) 时按需释放多克索鲁比 (DOX),显示出癌症治疗的前景.

科学领域:

聚合物化学聚合物化学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

开发用于控制药物输送的多功能纳米平台至关重要.
反应性氧物种 (ROS) 是癌症治疗的关键目标.
可见光触发的交叉连接在纳米医学中提供了时空控制.

研究的目的:

设计和合成可见光诱导的disenide-crosslinked聚氨微粒.
评估它们作为多克索鲁比 (DOX) 的ROS触发药物递送系统的潜力.
评估微粒的稳定性,药物释放概况和细胞毒性.

主要方法:

合成了一种两性块共聚合物 (PEG-b-PUSe-b-PEG) 与迪塞伦基.
自组装成小粒,并封装DOX.
可见光触发的微细胞核通过Se-Se键转化在位交联.
在不同的条件下,粒子大小,体稳定性和体外药物释放的表征.
使用MTT测定和细胞吸收研究进行细胞毒性评估.

主要成果:

与非交叉连接的小粒 (NCLM) 相比,disenide交叉连接的小粒 (CLM) 显示出较小的颗粒大小和增强的体稳定性.
在生理条件下,CLM表现出抑制的DOX释放,但在氧化环境中触发了突发释放.
交叉连接的聚氨菌根对HeLa细胞没有显著的细胞毒性.
观察到有效的细胞吸收和细胞内DOX释放.

结论:

可见光诱导的disenide-crosslinked聚氨小粒代表了一个有前途的ROS响应药物递送系统.
可逆交叉连接机制允许按需释放药物.
这个平台具有针对性癌症治疗的巨大潜力.

关键词:

ROS 的响应能力.交叉连接交叉连接这种化物是化物.药物输送是药物输送的过程.可见光敏感度对可见光的敏感度

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