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阿司匹林干预对炎症相关的语言细菌的影响:来自随机临床试验的试点研究

Guillaume C Onyeaghala¹, Shweta Sharma², Mosunmoluwa Oyenuga³

¹Division of Nephrology, Hennepin Healthcare, University of Minnesota, Minneapolis, MN 55415, USA.

|August 29, 2024

概括

阿司匹林干预改变了与炎症性肠道疾病和结直肠癌 (CRC) 相关的口腔细菌. 这项试点研究表明,阿司匹林可能会改变口腔微生物群,这可能对预防疾病产生潜在影响.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

口腔细菌与炎症性肠病 (IBD) 和结肠直肠癌 (CRC) 有关.
阿司匹林正在研究其潜在的化学预防作用.

研究的目的:

研究六周的阿司匹林干预对健康成年人特定口腔细菌种类的相对丰度的影响.
为了确定与阿司匹林使用相关的潜在口腔微生物生物标志物.

主要方法:

一个试点随机的安慰剂受控试验,涉及50名健康受试者 (50-75岁).
参与者每天一次口服325毫克阿司匹林或安慰剂,持续6周.
在基线和第六周采集了口腔舌头拭子以进行细菌分析.

主要成果:

与安慰剂相比,阿司匹林干预显著改变了与安慰剂相比,八种口服细菌属的相对丰度.
亚司匹林增加了 * 尼塞利亚 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * * 菌株 * *
阿司匹林降低了Prevotella,Veillonella,Fusobacterium和Porphyromonas,而Neisseria和Fusobacterium的比例显著下降.

结论:

阿司匹林干预显然改变了健康成年人的口腔微生物组合.
在特定细菌种群中观察到的变化,特别是Neisseria*/Fusobacterium*比率,可能作为阿司匹林干预的潜在生物标志物.
建议使用元基因组测序进行进一步验证,以阐明阿司匹林在口腔生态中的作用.

关键词:

阿司匹林是一种阿司匹林.结肠直肠癌是什么意思口腔微生物组是口腔的微生物组.牙周炎是指牙周炎的一种疾病.

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