微生物群和重复妊娠损失 (RPL);不仅仅是一个简单的连接
Jenny Valentina Garmendia1, Claudia Valentina De Sanctis1, Marián Hajdúch1,2,3
1Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hněvotínská 1333/5, 779 00 Olomouc, Czech Republic.
Microorganisms
|August 29, 2024
概括
重复流产 (RPL) 可能与阴道和肠道微生物群不平衡有关,特别是 Lactobacillus crispatus 的减少. 调节微生物群可能会改善怀孕的结果.
科学领域:
- 生殖免疫学 生殖免疫学
- 微生物组研究的研究.
- 妇女健康 妇女健康
背景情况:
- 复发性流产 (RPL) 影响1-2%的女性,原因不明.
- 阴道,子宫内膜和肠道微生物群越来越多地与RPL有关.
- 减少Lactobacillus crispatus与增加的炎症和免疫激活有关,有助于妊娠流产.
研究的目的:
- 探索局部和肠道微生物群在重复流产 (RPL) 中的作用.
- 研究微生物失衡对与怀孕相关的免疫反应的影响.
主要方法:
- 审查现有关于RPL微生物群组成的研究.
- 细菌结构和代谢物的免疫细胞调节的分析.
- 检查肠道微生物群对系统和局部免疫细胞的影响.
主要成果:
- 乳酸菌克里斯帕图斯的减少与阴道和子宫内膜炎症的增加有关.
- 支持炎症的Th1/Th17细胞和减少的Treg/NK细胞有助于流产.
- 肠道微生物群的代谢物可能会促进向生殖组织迁移的促炎性淋巴细胞.
结论:
- 微生物群分析可能对描述一些RPL患者至关重要.
- 虽然口服益生菌对当地微生物群的直接影响尚未被证明,但它们的代谢物可能会带来好处.
- 阴道Lactobacillus crispatus移植和对微生物群调节的进一步研究是改善RPL怀孕成功的有希望的途径.
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