尼辛是一种益生菌细菌素,调节女性生殖器官的炎症和微生物组变化,由多微生物牙周感染介导
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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
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Changchang Ye1,2, Chuanjiang Zhao1,3, Ryutaro Kuraji1,4
1Orofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.
Microorganisms
|August 29, 2024
概括
牙周炎可能会对女性生殖系统产生负面影响. 这项研究表明,益生菌细菌素尼可以调节生殖微生物组,并减少牙周炎引起的炎症.
科学领域:
- 微生物学 微生物学
- 生殖科学 生殖科学
- 免疫学 免疫学 免疫学
背景情况:
- 与牙周炎相关的口腔微生物失生症与不良妊娠结果,不孕症和生殖系统炎症有关.
- 益生菌提供了一个潜在的策略来调节口腔微生物组,并减轻牙周炎相关的问题.
研究的目的:
- 为了研究益生菌细菌素尼对生殖微生物群和炎症在牙周炎的小鼠模型的影响.
- 评估尼在治疗牙周炎引起的生殖道变化的治疗潜力.
主要方法:
- 使用*Porphyromonas gingivalis*,*Treponema denticola*,*Tannerella forsythia*和*Fusobacterium nucleatum*建立了一种牙周病的多微生物小鼠模型.
- 小鼠被分为控制,感染,尼和感染+尼组.
- 16S rRNA测序和RT-PCR被用于分析生殖器官,口腔,心脏和大动脉中的微生物组合和炎症性细胞因子水平.
主要成果:
- 在生殖器官,心脏和大动脉中检测到牙周病原体,这表明系统性传播.
- 多微生物感染降低了子宫微生物群的多样性和改变了细菌组成 (较低的*Firmicutes*,更高的*Bacteroidota*),由nisin.
- 尼辛治疗减少了口腔内特定的牙周病原体,并调节了生殖道微生物组,增加了*蛋白质细菌*并减少了*菌菌和*细菌菌*.
- 牙周炎增加了子宫和口腔炎性细胞因子 (IL-6,TNF-α),这些细胞因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子因子).
结论:
- 多微生物牙周病显著改变生殖道的微生物特征,微生物组合和炎症状态.
- 尼辛有效调节生殖道微生物群,减轻牙周炎引起的子宫炎症.
- 这些发现凸显了尼作为治疗性牙周炎相关生殖健康问题的治疗剂的潜力.
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