相关实验视频

Updated: Jun 14, 2025

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

萨卡罗米克斯花菌对肝脏疾病的影响:系统性审查

Roman Maslennikov¹, Nona Benuni¹, Anna Levshina¹

¹Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow 119435, Russia.

|August 29, 2024

概括

在治疗肝硬化和代谢功能障碍相关的脂肪性肝病 (MASLD) 等肝脏疾病方面,Saccharomyces boulardii (SB) 是有前途的. 这种益生菌减少炎症,纤维化,并改善肠道屏障功能在各种研究中.

科学领域:

肝病学肝病学是一种肝病学.
胃肠病学胃肠病学
微生物学微生物学

背景情况:

肝脏疾病代表着全球健康的重大负担.
新兴研究探讨了益生菌在治疗肝脏疾病中的作用.
糖菌 (Saccharomyces boulardii,简称SB) 是一种众所周知的益生菌酵母,具有潜在的治疗应用.

研究的目的:

系统地审查和综合已发表的关于Saccharomyces boulardii (SB) 在治疗各种肝脏疾病中的疗效研究结果.
在肝病模型中评估SB对生化标志物,炎症途径,纤维化和肠道微生物群的影响.

主要方法:

在PubMed和Scopus数据库中进行了全面的文献搜索.
包括的研究包括十项实验性动物研究 (EAS) 和六项随机对照试验 (RCT).
在包括的研究中,主要使用的是SB的CNCM I-745菌株.

主要成果:

SB治疗导致肝硬化表现的严重程度降低,并改善了RCT中的Child-Pugh得分.
在MASLD模型中,SB降低了TNF-α,IL-1β,IL-6和IL-4的血清水平,并减少了肝硬化和炎症.
通过减少TGF-β,α-SMA和原基因的表达,以及积极调节肠道微生物群组成和屏障功能,SB减轻了肝纤维化.

结论:

在治疗各种肝脏疾病方面,Saccharomyces boulardii具有显著的治疗潜力,包括肝硬化和MASLD.
SB通过抗炎,抗纤维和肠道保护机制发挥作用.
需要进一步的临床研究来确定SB作为肝脏疾病的标准治疗方法.

关键词:

这种疾病叫做dysbiosis.肠肝轴肠肝轴肠肝轴肠道的通透性肠道的通透性有泄漏的肠道微生物组是一个微生物组.我们的微生物群.益生菌是一种益生菌.

更多相关视频

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

相关概念视频

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Lysosomal Hydrolases

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...