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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
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多通道微尺度神经手用于空间选择性神经调节

Morgan Riley1, Fnu Tala2, Katherine J Johnson3

  • 1Biomedical Engineering Doctoral Program, Boise State University, Boise, ID 83725, USA.

Micromachines
|August 29, 2024
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概括

研究人员开发了一种新的,具有成本效益的方法,用于制造高分辨率的神经手. 这一突破使选择性神经刺激成为可能,为各种疾病推进神经调节疗法.

关键词:
的手套.定制的定制的定制的定制在微观尺度上多通道的多通道服务.通过神经调节进行神经调节.有选择性的选择性选择性.

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科学领域:

  • 生物医学工程 生物医学工程
  • 神经科学是一个神经科学.
  • 医疗器械 医疗器械

背景情况:

  • 电刺激用于外围神经调节具有治疗潜力,但选择性差和副作用不佳.
  • 现有的商业神经袖子很昂贵,缺乏空间分辨率,而定制设计的袖子需要专门的制造.
  • 在原型神经袖口的困难阻碍了选择性神经调节的研究.

研究的目的:

  • 开发一种可重复的,具有成本效益的方法,用于制造用于选择性带神经调节的多通道上神经袖口.
  • 为了创建可定制的神经袖口,具有高空间分辨率,用于急性神经调节研究.

主要方法:

  • 利用商业灵活印刷电路 (FPC) 技术,制造具有可调节电极大小,通道数量和直径的神经袖口.
  • 设计用于成年老鼠和老鼠坐骨神经 (300-1500微米直径) 的袖口.
  • 用PEDOT:PSS涂层的电极增强了充电注入能力,并使用微计算断层扫描 (μCT) 验证了选择性.

主要成果:

  • 通过使用FPC技术,成功制造出高分辨率 (50微米) 神经袖口.
  • 已在老鼠和小鼠中证明了选择性神经调节,实现了前 (TA) 和侧胃半 (LG) 肌肉的优先激活.
  • 使用选择性指数量化选择性,确认该方法的有效性.

结论:

  • 开发的制造方法使多通道脊髓神经袖口的快速和经济有效的原型设计成为可能.
  • 这种方法通过克服现有技术的局限性,促进了选择性带神经调节的研究.
  • 该方法具有很大的潜力,可以促进针对性神经刺激疗法的研究和应用.