脂肪乳液类型和肝功能在腹腔营养患者:患者和处方实践的回顾性研究
Marvick Melendez1, Ronelle Mitchell1, Hannah Heredia1
1Optum Home Infusion Services, 8509 Benjamin Rd., Tampa, FL 33364, USA.
Nutrients
|August 29, 2024
概括
在家庭亲肠道营养 (HPN) 中使用的不同静脉注射脂类乳液 (ILEs) 在成人患者的六个月内没有显著改变肝功能测试 (LFTs). 这表明ILE的组成可能不会影响HPN的肝脏健康.
科学领域:
- 临床营养学 临床营养学
- 胃肠病学 胃肠病学
- 患者护理 患者护理
背景情况:
- 亲肠道营养 (PN) 对无法通过口腔或肠道获得足够营养的患者至关重要.
- PN的脂质组成,特别是静脉脂质乳液 (ILEs),对肝病患者来说是一个潜在的关注点.
- 了解IE的处方实践及其对家庭PN (HPN) 肝功能的影响是必要的.
研究的目的:
- 调查成年HPN患者中ILEs的处方模式.
- 为了确定不同类型的ILEs是否会影响六个月的肝功能测试 (LFTs).
主要方法:
- 一项回顾性研究分析了105名成年HPN患者6个月的每月LFT (ALP,ALT,AST,总 bilirubin).
- 患者接受了橄油/大豆油,混合ILE,大豆油或没有ILE.
- 基线特征和LFTs在各组之间进行了比较.
主要成果:
- 在ILE组之间没有观察到基线LFT,年龄,BMI,PN持续时间或体积的显著差异.
- 对于LFTs,没有发现ILE类型和时间之间的显著相互作用.
- 无论是ILE类型还是时间都没有显著影响LFT,平均LFT在六个月的ILE类型之间没有差异.
结论:
- 大多数HPN患者接受了混合ILE或与多个脂质来源的ILE.
- 在长期HPN中使用的IE类型在六个月的研究期间没有改变LFT.
- 这些发现表明,不同的ILE组合可能不会显著影响HPN患者的肝功能.
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