高蛋白质营养补充剂改善了系统性硬化症的营养不良患者的营养状况
Anna Wojteczek1, Jolanta Dardzińska2, Marcin Ziętkiewicz1
1Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Nutrients
|August 29, 2024
概括
系统性硬化症 (SSc) 患者经常遭受营养不良. 一种高蛋白口服营养补充剂 (ONS) 有效地改善了营养不良的SSc患者的营养状况,并使其稳定在预先的个体中.
科学领域:
- 营养科学 营养科学
- 类风湿病学 类风湿病学
- 临床研究 临床研究
背景情况:
- 营养状况下降是患有全身性硬化症 (SSc) 的患者普遍存在的问题.
- 识别前缓解症和营养不良对于管理SSc患者至关重要.
- 营养缺陷可以显著影响SSc.个体的健康和预后.
研究的目的:
- 在患有全身性硬化症 (SSc) 的患者中识别前和营养不良.
- 评估高蛋白口服营养补充剂 (ONS) 在改善SSc患者的营养状况方面的有效性.
- 评估营养干预对SSc患者的长期影响.
主要方法:
- 56名SSc患者和49名健康对照的队列接受了临床评估,生物电阻分析 (BIA) 和实验室测试.
- SSc患者被分为营养良好,预先失禁和营养不良的组.
- 营养不平衡的SSc患者每天接受3个月的高蛋白ONS,并在3个月和12个月重新评估.
主要成果:
- 与对照组相比,SSc患者的SGA值,瘦组织质量 (LTM) 和瘦组织指数 (LTI) 显著降低.
- 在56名SSc患者中,71.4%的患者营养良好,8.9%的患者患有前症,而19.7%的患者营养不良.
- 高蛋白质的ONS稳定了前病患者的营养标志物,并在营养不良患者中显著改善了SGA,LTI和LTM,在12个月后持续作用.
结论:
- 营养不良是系统性硬化症 (SSc) 的常见和重大并发症.
- 使用高蛋白ONS的营养干预可以有效地改善和稳定SSc患者的营养状况.
- 对营养不良的早期发现和干预对于管理SSc患者至关重要.
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