虚弱与老年CKD患者的营养不良-炎症综合征有关
Paolo Molinari1, Lara Caldiroli1, Matteo Abinti1
1Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.
Nutrients
|August 29, 2024
概括
在患有晚期慢性病 (CKD) 的老年人中,虚弱与营养不良-炎症综合征密切相关. 然而,循环的炎症性细胞因子与这组患者的整体脆弱性没有直接关联.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 炎症学 炎症学
背景情况:
- 患有慢性病 (CKD) 的老年人通常与正常功能的人相比,表现出更大的脆弱性.
- 虚弱,营养不良-炎症综合征和炎症性细胞因子是影响老龄人口健康结果的关键因素.
研究的目的:
- 为了研究脆弱性,营养不良-炎症综合征和循环炎症细胞因子之间的横截面关联,在晚期CKD的老年人中进行.
- 为了确定晚期CKD的脆弱性是否与特定的炎症标志物或营养不良-炎症综合征独立相关.
主要方法:
- 评估了115名患有晚期CKD的老年人,使用弗里德的脆弱表型 (FP) 和营养不良-炎症评分 (MIS).
- 评估循环炎症细胞因子,包括IL-6,TNFα和MCP-1.
- 采用多变量回归分析来识别独立的关联.
主要成果:
- 在115名患者中,有48名患者被归类为脆弱患者,在脆弱和非脆弱组之间,估计的淋巴细胞过率 (eGFR) 是可比的.
- 虚弱的患者表现出明显更高的MIS得分 (p < 0.0001),但类似的炎症性细胞因子度.
- 多变量分析显示FP与MIS,年龄,性别和前专辑蛋白独立相关,但与细胞因子水平没有直接关联.
结论:
- 在晚期CKD的老年患者中,虚弱与营养不良-炎症综合征密切相关.
- 没有发现循环炎症细胞因子与这个队列的整体脆弱性表型独立相关.
- 具体的脆弱性标准,如减肥,缓慢和软弱,与某些细胞因子 (MCP-1,IL-6) 有关.
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