基因多形态对认知功能的影响 根据西班牙学生样本中对双醇的饮食暴露
Viviana Ramírez1,2,3,4, Patricia González-Palacios1,3, Pablo José González-Domenech5
1Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
Nutrients
|August 29, 2024
概括
遗传变异和环境因素,如双醇暴露会影响神经发育障碍. 这项研究发现了影响儿童认知功能的特定基因-双相互作用,为NDD提供了洞察力.
科学领域:
- 环境表观遗传学环境表观遗传学
- 神经科学是一个神经科学.
- 人类遗传学 人类遗传学
背景情况:
- 神经发育障碍 (NDD) 受遗传和环境因素的影响.
- 内分泌干扰化学物质 (EDC),如双甲 (BPA),被认为是神经内分泌干扰物.
- 了解基因与环境的相互作用对于NDD研究至关重要.
研究的目的:
- 研究遗传多态性 (SNP) 对西班牙学童认知功能的影响.
- 评估食双暴露在调节认知表现中的作用.
- 探索特定遗传变异和双暴露之间的潜在相互作用.
主要方法:
- 在102名儿童 (6-12岁) 中,在与大脑功能相关的基因 (例如,BDNF,SNAP25) 中对10个SNP进行基因定型.
- 通过饮食暴露于双醇 (BPA和BPS) 的估计.
- 使用西班牙语形式的WISC-V评估认知功能.
主要成果:
- 特定的BDNF和SNAP25等位基因与更好的流体推理有关,但BDNF变异与较低的分数相关,这是一个显著的例外.
- 在语言理解,工作记忆和流动推理方面发现了SNP和双暴露之间的显著相互作用.
- 确定了特定的SNP (例如NTRK2,HTR2A,MTHFR,OXTR,SLC6A2) 和它们的相互作用p值.
结论:
- 这项研究提供了遗传变异性和双暴露对认知功能的联合影响的初步证据.
- 这些发现凸显了NDD的复杂,多因素的病因.
- 对基因与环境相互作用的进一步研究对于理解NDD至关重要.
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