相关实验视频
Updated: Jun 14, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.2K
功能性运动能力能否影响晚期慢性病患者的死亡率?
Ángel Nogueira-Pérez1,2, Paloma Ruiz-López-Alvarado2, Guillermina Barril-Cuadrado2,3
1Avericum, 35220 Las Palmas, Spain.
Nutrients
|August 29, 2024
概括
功能能力显著影响晚期慢性病 (ACKD) 患者的死亡风险. 身体功能受损和炎症增加死亡率,而良好的功能能力,特别是通过短物理性能电池 (SPPB),可以降低死亡率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 营养状况和身体组成的变化在晚期慢性病 (ACKD) 中很常见.
- 这些变化会影响功能,增加死亡风险.
- 评估功能能力对于理解ACKD的预后至关重要.
研究的目的:
- 确定功能能力对ACKD患者死亡率的影响.
- 评估各种功能测试,以评估它们对死亡率的预测价值.
- 探索身体组成,营养状况和ACKD死亡率之间的关系.
主要方法:
- 一项前性观察性研究对225名ACKD患者进行了8年的跟踪.
- 功能能力通过使用短物理性能电池 (SPPB),6分钟步行测试,定时起步和起步以及坐立测试来评估.
- 评估了身体组成,营养标志物 (白蛋白,CRP),肌肉强度,并发症和脆弱性;使用Cox比例危险模型分析死亡率.
主要成果:
- 在研究期间,有50名患者死亡.
- 功能和肌肉强度测试中的表现较差与较差的身体组成,营养状况和寿命缩短有关.
- 炎症 (CRP) 与死亡率增加有关 (HR=1.333),而良好的SPPB表现降低了死亡风险 (HR=0.778).
结论:
- 功能能力是ACKD患者全因死亡率的重要预测因素.
- 功能障碍,无论使用哪种测试,都与较高的死亡率有关.
- 在ACKD中,SPPB是评估功能能力和死亡风险的宝贵工具,支持其融入全面的患者护理.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
62
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
62
01:11Renal Failure: Dose Adjustments
69
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
69
01:27Dialysis
277
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
277
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K